Improving clinical outcomes in sepsis and multiple organ dysfunction through precision medicine
نویسندگان
چکیده
منابع مشابه
Epidemiology of sepsis and multiple organ dysfunction syndrome in children.
STUDY OBJECTIVES To determine the cumulated incidence and the density of incidence of systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, and multiple organ dysfunction syndrome (MODS) in critically ill children; to distinguish patients with primary from those with secondary MODS. DESIGN Prospective cohort study. SETTING Pediatric ICU of a university hospita...
متن کاملThe evolution and therapy aspects in multiple organ dysfunction sepsis
Background Severe sepsis was the subject of intense debate over the years, and in the last twenty years there has been a constant effort to identify therapies that reduce mortality. Although the inflammatory response is often adapted to the etiologic agent and to the increase of the mediators in association with organ dysfunction, it is not currently possible to rapidly assess the patients’ abi...
متن کاملMild hypothermia in improving multiple organ dysfunction after cardiac arrest.
BACKGROUND Resuscitation after cardiac arrest (CA) with a whole-body ischemia-reperfusion injury causes brain injury and multiple organ dysfunction (MODS). This study aimed to determine whether mild systemic hypothermia could decrease multiple organ dysfunctions after resuscitation from cardiac arrest. METHODS The patients who had been resuscitated after cardiac arrest were reviewed. During t...
متن کاملThe Relationship between Plasma Levels of Interleukin-6, Multiple Organ Dysfunction and Mortality in Orthopedic Patients
Background: Interleukin 6 (IL-6) functions as both a pro-inflammatory cytokine and an anti-inflammatory cytokine. Objective: To evaluate the levels of IL-6 in patients with multiple organ dysfunction syndrome (MODS). Methods: Level of IL-6 was assessed and recorded for 14 days subsequent to the injury in 161 multiple trauma patients. MODS were diagnosed using Marshal Score. Injury Severity Scor...
متن کاملTowards precision medicine for sepsis patients
Over the last decade it has become clear that the immunological response and clinical course in sepsis patients is too complex to simply regard it as ‘hyperinflammation-induced organ failure’. In contrast to the previous belief that patients mainly suffer from an exaggerated pro-inflammatory response, it has now become evident that a proand anti-inflammatory response are mounted simultaneously ...
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ژورنال
عنوان ژورنال: Journal of Thoracic Disease
سال: 2019
ISSN: 2072-1439,2077-6624
DOI: 10.21037/jtd.2018.11.74